Methotrexate and self-isolation for Covid-19 (coronavirus)

We have received queries about whether women receiving methotrexate treatment for ectopic pregnancy need to self-isolate. We have been in touch with our medical advisers on this question in light of evolving circumstances regarding coronavirus.

Methotrexate is an immunosuppressant when used for a long time to treat auto-immune diseases and skin conditions. The methotrexate regimen used for ectopic pregnancy is different; it is given in a maximum of two one-off doses to women with healthy immune systems and normal white cell counts. White blood cells fight infections. Very rarely, methotrexate causes the white cell count to fall and if this happens it could potentially impact their immune systems. In our medical advisers’ experience, this side effect is very rare and should neither prevent methotrexate being used, nor prompt women to routinely self-isolate after having methotrexate.

If you are showing symptoms of coronavirus, please follow Government guidelines on self-isolation.